DNA oligonucleotides with stereodefined phenylphosphonate and phosphonothioate internucleotide bonds: synthesis and physico-chemical properties
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چکیده
منابع مشابه
extraction and acetylation of purified trypsin from bovin pancreas and study of some its physico-chemical properties
آنزیم تریپسین در شرایط قلیایی ناپایدار می باشد .و فعالیت پروتئولیتیکی تریپسین منجربه خود هضمی آن در جایگاههای خاصی می گردد. بنابر این آنزیمی با ناپایداری بالا محسوب میگردد. در سالهای اخیر موفق شدند که با ایجاد تغیرات شیمیایی با اضافه کردن فلزات خاص ، کلسیم و یا عمل استیلاسیون منجر به افزایش پایداری آنزیم تریپسین گردند. مطالعات در حال حاضر نشان می دهد که تریپسین استیله شده فعالیت آنزیمی خود را ...
15 صفحه اولSynthesis and DNA binding affinity of irregular sequence oligonucleotides with triazole internucleotide linkages
A novel class of backbone-modified oligonucleotide analogs has emerged since the discovery of Cu-catalyzed 3+2 azide-alkyne cycloaddition. These are oligonucleotide analogs with 1,4-substituted 1,2,3-triazoles in internucleotide linkages. Of all such analogs known to date, only the triazole-linked deoxythymidine decamer has been reported to show enhanced binding affinity to complementary DNA....
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2011
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0013.407